TY - JOUR
T1 - Biomembrane-based organic electronic devices for ligand-receptor binding studies.
AU - Liu, Han-Yuan
AU - Pappa, Anna-Maria
AU - Hidalgo, Tania Cecilia
AU - Inal, Sahika
AU - Owens, Rόisín M
AU - Daniel, Susan
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Professor Nam-Joon Cho (the Engineering in Translational Science Group at Nanyang Technical University) for his advice and providing the microfluidic flow cells used in this work. The views and conclusions contained in this document are those of the authors
and should not be interpreted as representing the official policies, either expressed or implied, of DARPA or the Army Research Office or the U.S.Government.
PY - 2020/2/6
Y1 - 2020/2/6
N2 - We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent binding interactions. Because these polymers are transparent and conducting, we demonstrate, by optical and electrical detection, the specific interactions of proteins with these biomembrane-based bioelectronic devices. This work paves the way for easy formation of biomembrane mimetics for sensing and detection of binding events in a label-free manner on organic electronic devices of more sophisticated architectures. Graphical abstract.
AB - We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent binding interactions. Because these polymers are transparent and conducting, we demonstrate, by optical and electrical detection, the specific interactions of proteins with these biomembrane-based bioelectronic devices. This work paves the way for easy formation of biomembrane mimetics for sensing and detection of binding events in a label-free manner on organic electronic devices of more sophisticated architectures. Graphical abstract.
UR - http://hdl.handle.net/10754/661484
UR - http://link.springer.com/10.1007/s00216-020-02449-3
UR - http://www.scopus.com/inward/record.url?scp=85079193996&partnerID=8YFLogxK
U2 - 10.1007/s00216-020-02449-3
DO - 10.1007/s00216-020-02449-3
M3 - Article
C2 - 32020319
SN - 1618-2642
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
ER -