Bolaamphiphiles based novel liposomes: a possible approach for drug delivery

Bhuvaneshwar Vaidya, Amit K. Goyal, Kapil Khatri, Neeraj Mishra, Rishi Paliwal, Shivani Rai, Shailja Tiwari, Suresh P. Vyas, Suresh P. Vyas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The present study was designed to develop a novel liposomal system containing dequalinium chloride (DEQ) as a charge-imparting constituent. Liposomes were prepared by cast film method with EPC: chol: DEQ molar ratio of 7:1:2. The novel liposomes were characterised for surface morphology, size and size distribution, entrapment efficiency and in vitro release study. Effect of osmotic shock was performed for establishment of liposomal bilayer stability and results demonstrated that incorporation of dequalinium chloride to the liposomal bilayer hindered the movement of entrapped solute. The hemolysis study was performed for estimation of its toxicological behaviour, if any. Cell-uptake studies showed that developed carrier could be useful for higher penetration in the cells compared to conventional liposomes. This being the first finding of its kind could open up a new era for the use of bolaamphiphiles like DEQ as an integral part of well established carrier like liposomes to provide them additional stability and efficacy. © 2010 Inderscience Enterprises Ltd.
Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalInternational Journal of Biomedical Nanoscience and Nanotechnology
Issue number2-4
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)


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