Brønsted-acid-catalyzed activation of nitroalkanes: A direct enantioselective aza-henry reaction

Magnus Rueping; Andrey P. Antonchick

doi:10.1021/ol8003589

Brønsted-acid-catalyzed activation of nitroalkanes: A direct enantioselective aza-henry reaction

Magnus Rueping^*, Andrey P. Antonchick

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifuctlonal Bronsted-acid-catalyzed activation of nitroalkanes provides an efficient access to α,β-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.

Original language	English (US)
Pages (from-to)	1731-1734
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	9
DOIs	https://doi.org/10.1021/ol8003589
State	Published - May 1 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol8003589

Cite this

@article{90d898a9e46f4f6193c607ee9c5acfb0,

title = "Br{\o}nsted-acid-catalyzed activation of nitroalkanes: A direct enantioselective aza-henry reaction",

abstract = "A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifuctlonal Bronsted-acid-catalyzed activation of nitroalkanes provides an efficient access to α,β-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.",

author = "Magnus Rueping and Antonchick, {Andrey P.}",

year = "2008",

month = may,

day = "1",

doi = "10.1021/ol8003589",

language = "English (US)",

volume = "10",

pages = "1731--1734",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Brønsted-acid-catalyzed activation of nitroalkanes

T2 - A direct enantioselective aza-henry reaction

AU - Rueping, Magnus

AU - Antonchick, Andrey P.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifuctlonal Bronsted-acid-catalyzed activation of nitroalkanes provides an efficient access to α,β-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.

AB - A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifuctlonal Bronsted-acid-catalyzed activation of nitroalkanes provides an efficient access to α,β-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.

UR - http://www.scopus.com/inward/record.url?scp=53249083582&partnerID=8YFLogxK

U2 - 10.1021/ol8003589

DO - 10.1021/ol8003589

M3 - Article

C2 - 18393508

AN - SCOPUS:53249083582

SN - 1523-7060

VL - 10

SP - 1731

EP - 1734

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Brønsted-acid-catalyzed activation of nitroalkanes: A direct enantioselective aza-henry reaction

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this