Abstract
The synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Brønsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ-lactams, with good functional group tolerance and high yields.
Original language | English (US) |
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Pages (from-to) | 14054-14058 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 24 |
Issue number | 53 |
DOIs | |
State | Published - Sep 20 2018 |
Keywords
- Brønsted base
- lactam derivatives
- photoredox catalysis
- proton-coupled electron transfer (PCET)
- radical reactions
- sulfonyl radical
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Organic Chemistry