TY - JOUR
T1 - Brain energy metabolism
T2 - Focus on Astrocyte-neuron metabolic cooperation
AU - Bélanger, Mireille
AU - Allaman, Igor
AU - Magistretti, Pierre J.
N1 - Funding Information:
We apologize to those authors whose original work could not be referenced due to space constraints. This work was supported by a grant from the Swiss National Science Foundation (FNRS) to P.J.M. (number 3100AO-108336/1). P.J.M. is the recipient of the Asterion Foundation Chair.
PY - 2011/12/7
Y1 - 2011/12/7
N2 - The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes - a type of glial cell - have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
AB - The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes - a type of glial cell - have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
UR - http://www.scopus.com/inward/record.url?scp=82955168362&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2011.08.016
DO - 10.1016/j.cmet.2011.08.016
M3 - Review article
C2 - 22152301
AN - SCOPUS:82955168362
SN - 1550-4131
VL - 14
SP - 724
EP - 738
JO - Cell Metabolism
JF - Cell Metabolism
IS - 6
ER -