Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells

G. Simone; N. Malara; P. Neuzil; E. Di Fabrizio; A. Manz

Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells

G. Simone, N. Malara, P. Neuzil, E. Di Fabrizio, A. Manz

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Isolation of metastatic circulating tumor cells (CTCs) is still a challenge as well as to develop a surveillance strategy for early cancer detection. The principal difficulty is the identification of the metastatic sub-population belonging to the heterogeneous circulating cells. Here we present carbohydrate use for specific binding assay to isolate metastatic circulating tumor cells (CTCs). In this assay we took advantage to explore the specificity of carbohydrate-protein complex responsible of the tumour cell extravasations, mimicking in vivo multivalent interactions. The assay resulted efficient in dealing CMCs (specificity of 68% and captures efficiency of 82%).

Original language	English (US)
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	100-102
Number of pages	3
Volume	1
State	Published - 2011
Externally published	Yes
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: Oct 2 2011 → Oct 6 2011

Other

Other	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/Territory	United States
City	Seattle, WA
Period	10/2/11 → 10/6/11

Keywords

Carbohydrate-protein complex
Early detection
Metastasis

ASJC Scopus subject areas

Control and Systems Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@inproceedings{49fe0241b77d41aaad489de9bc544dcd,

title = "Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells",

abstract = "Isolation of metastatic circulating tumor cells (CTCs) is still a challenge as well as to develop a surveillance strategy for early cancer detection. The principal difficulty is the identification of the metastatic sub-population belonging to the heterogeneous circulating cells. Here we present carbohydrate use for specific binding assay to isolate metastatic circulating tumor cells (CTCs). In this assay we took advantage to explore the specificity of carbohydrate-protein complex responsible of the tumour cell extravasations, mimicking in vivo multivalent interactions. The assay resulted efficient in dealing CMCs (specificity of 68% and captures efficiency of 82%).",

keywords = "Carbohydrate-protein complex, Early detection, Metastasis",

author = "G. Simone and N. Malara and P. Neuzil and {Di Fabrizio}, E. and A. Manz",

year = "2011",

language = "English (US)",

isbn = "9781618395955",

volume = "1",

pages = "100--102",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",

}

Simone, G, Malara, N, Neuzil, P, Di Fabrizio, E & Manz, A 2011, Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 1, pp. 100-102, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 10/2/11.

Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells. / Simone, G.; Malara, N.; Neuzil, P. et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. p. 100-102.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells

AU - Simone, G.

AU - Malara, N.

AU - Neuzil, P.

AU - Di Fabrizio, E.

AU - Manz, A.

PY - 2011

Y1 - 2011

N2 - Isolation of metastatic circulating tumor cells (CTCs) is still a challenge as well as to develop a surveillance strategy for early cancer detection. The principal difficulty is the identification of the metastatic sub-population belonging to the heterogeneous circulating cells. Here we present carbohydrate use for specific binding assay to isolate metastatic circulating tumor cells (CTCs). In this assay we took advantage to explore the specificity of carbohydrate-protein complex responsible of the tumour cell extravasations, mimicking in vivo multivalent interactions. The assay resulted efficient in dealing CMCs (specificity of 68% and captures efficiency of 82%).

AB - Isolation of metastatic circulating tumor cells (CTCs) is still a challenge as well as to develop a surveillance strategy for early cancer detection. The principal difficulty is the identification of the metastatic sub-population belonging to the heterogeneous circulating cells. Here we present carbohydrate use for specific binding assay to isolate metastatic circulating tumor cells (CTCs). In this assay we took advantage to explore the specificity of carbohydrate-protein complex responsible of the tumour cell extravasations, mimicking in vivo multivalent interactions. The assay resulted efficient in dealing CMCs (specificity of 68% and captures efficiency of 82%).

KW - Carbohydrate-protein complex

KW - Early detection

KW - Metastasis

UR - http://www.scopus.com/inward/record.url?scp=84883773973&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84883773973

SN - 9781618395955

VL - 1

SP - 100

EP - 102

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Y2 - 2 October 2011 through 6 October 2011

ER -

Carbohydrate-protein complex for specifically isolating metastatic circulating cancer cells

Abstract

Other

Keywords

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this