Catalytic α-arylation of imines leading to N-unprotected indoles and azaindoles

Enrico Marelli, Martin Corpet, Yury Minenkov, Rifahath Neyyappadath, Alessandro Bismuto, Giulia Buccolini, Massimiliano Curcio, Luigi Cavallo, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


A Palladium-N-heterocyclic carbene-catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reactions pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point towards a deprotonative mechanism being operative.
Original languageEnglish (US)
Pages (from-to)2930-2938
Number of pages9
JournalACS Catalysis
Issue number5
StatePublished - Apr 7 2016


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