TY - JOUR
T1 - Catalytic α-arylation of imines leading to N-unprotected indoles and azaindoles
AU - Marelli, Enrico
AU - Corpet, Martin
AU - Minenkov, Yury
AU - Neyyappadath, Rifahath
AU - Bismuto, Alessandro
AU - Buccolini, Giulia
AU - Curcio, Massimiliano
AU - Cavallo, Luigi
AU - Nolan, Steven P.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Dr. Josè A. Fèrnandez-Sàlas, Dr. Fady Nahra, and
Dr. Marcel Brill for useful discussions. Dr. Sunil V. Sharma,
Dr. Cristina Pubil and Dr. Rebecca J. M. Goss are gratefully acknowledged for the help provided during the revision of
this manuscript. We thank ERC (FUNCAT to SPN) for funding.
We thank the EPSRC NMSSC in Swansea for mass spectrometric
analyses. The EPSRC is gratefully acknowledged
for financial support (Ph.D. studentships to AB, GB, MC and
RMN Through the doctoral training centre CRITICAT
EP/L016419/1).
PY - 2016/4/7
Y1 - 2016/4/7
N2 - A Palladium-N-heterocyclic carbene-catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reactions pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point towards a deprotonative mechanism being operative.
AB - A Palladium-N-heterocyclic carbene-catalyzed methodology for the synthesis of substituted, N-unprotected indoles and azaindoles is reported. The protocol permits access to various, highly substituted members of these classes of compounds. Although two possible reactions pathways (deprotonative and Heck-like) can be proposed, control experiments, supported by computational studies, point towards a deprotonative mechanism being operative.
UR - http://hdl.handle.net/10754/604381
UR - http://pubs.acs.org/doi/abs/10.1021/acscatal.6b00040
UR - http://www.scopus.com/inward/record.url?scp=84973621376&partnerID=8YFLogxK
U2 - 10.1021/acscatal.6b00040
DO - 10.1021/acscatal.6b00040
M3 - Article
C2 - 29291137
SN - 2155-5435
VL - 6
SP - 2930
EP - 2938
JO - ACS Catalysis
JF - ACS Catalysis
IS - 5
ER -