Catalytic asymmetric addition of aldehydes to oxocarbenium ions: A dual catalytic system for the synthesis of chromenes

Magnus Rueping; Chandra M.R. Volla; Iuliana Atodiresei

doi:10.1021/ol302084q

Catalytic asymmetric addition of aldehydes to oxocarbenium ions: A dual catalytic system for the synthesis of chromenes

Magnus Rueping^*, Chandra M.R. Volla, Iuliana Atodiresei

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.

Original language	English (US)
Pages (from-to)	4642-4645
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	17
DOIs	https://doi.org/10.1021/ol302084q
State	Published - Sep 7 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol302084q

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title = "Catalytic asymmetric addition of aldehydes to oxocarbenium ions: A dual catalytic system for the synthesis of chromenes",

abstract = "A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.",

author = "Magnus Rueping and Volla, {Chandra M.R.} and Iuliana Atodiresei",

year = "2012",

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T1 - Catalytic asymmetric addition of aldehydes to oxocarbenium ions

T2 - A dual catalytic system for the synthesis of chromenes

AU - Rueping, Magnus

AU - Volla, Chandra M.R.

AU - Atodiresei, Iuliana

PY - 2012/9/7

Y1 - 2012/9/7

N2 - A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.

AB - A synergistic catalytic system for the first asymmetric addition of aldehydes to in situ generated prochiral oxocarbenium ions has been developed. The dual catalytic protocol allows the simultaneous activation of both electrophile and nucleophile and provides access to a variety of valuable chiral 2H-chromenes with excellent enantioselectivities.

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U2 - 10.1021/ol302084q

DO - 10.1021/ol302084q

M3 - Article

C2 - 22913599

AN - SCOPUS:84866020856

SN - 1523-7060

VL - 14

SP - 4642

EP - 4645

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Catalytic asymmetric addition of aldehydes to oxocarbenium ions: A dual catalytic system for the synthesis of chromenes

Abstract

ASJC Scopus subject areas

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