Cell fate conversion by mRNA

Mo Li; Ignacio Sancho-Martinez; Juan Belmonte

doi:10.1186/scrt46

Cell fate conversion by mRNA

Mo Li, Ignacio Sancho-Martinez, Juan Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researchers and clinicians alike. It is hoped that this technology could contribute to unmet needs on several fronts of regenerative medicine, including mechanistic study of reprogramming, generation of safe induced pluripotent stem cells suitable for clinical applications, and derivation of desired cell types for cell-replacement therapy. We will discuss the technological advancements made by this synthetic mRNA methodology, its implications, as well as the challenges that lie ahead in the field of regenerative medicine.

Original language	English (US)
Article number	5
Journal	Stem Cell Research and Therapy
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/scrt46
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)
Molecular Medicine
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology

Access to Document

10.1186/scrt46

Cite this

@article{7d6b797ae7a74b96b9b4ce2533635e5f,

title = "Cell fate conversion by mRNA",

abstract = "Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researchers and clinicians alike. It is hoped that this technology could contribute to unmet needs on several fronts of regenerative medicine, including mechanistic study of reprogramming, generation of safe induced pluripotent stem cells suitable for clinical applications, and derivation of desired cell types for cell-replacement therapy. We will discuss the technological advancements made by this synthetic mRNA methodology, its implications, as well as the challenges that lie ahead in the field of regenerative medicine.",

author = "Mo Li and Ignacio Sancho-Martinez and Juan Belmonte",

note = "Funding Information: Work in the laboratory of JCIB was supported by the IPSEN Foundation.",

year = "2011",

doi = "10.1186/scrt46",

language = "English (US)",

volume = "2",

journal = "Stem Cell Research and Therapy",

issn = "1757-6512",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Cell fate conversion by mRNA

AU - Li, Mo

AU - Sancho-Martinez, Ignacio

AU - Belmonte, Juan

N1 - Funding Information: Work in the laboratory of JCIB was supported by the IPSEN Foundation.

PY - 2011

Y1 - 2011

N2 - Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researchers and clinicians alike. It is hoped that this technology could contribute to unmet needs on several fronts of regenerative medicine, including mechanistic study of reprogramming, generation of safe induced pluripotent stem cells suitable for clinical applications, and derivation of desired cell types for cell-replacement therapy. We will discuss the technological advancements made by this synthetic mRNA methodology, its implications, as well as the challenges that lie ahead in the field of regenerative medicine.

AB - Recent development of a synthetic mRNA-based technology for efficient reprogramming to pluripotency and cell fate conversion without any modification to the genome has generated great interest among researchers and clinicians alike. It is hoped that this technology could contribute to unmet needs on several fronts of regenerative medicine, including mechanistic study of reprogramming, generation of safe induced pluripotent stem cells suitable for clinical applications, and derivation of desired cell types for cell-replacement therapy. We will discuss the technological advancements made by this synthetic mRNA methodology, its implications, as well as the challenges that lie ahead in the field of regenerative medicine.

UR - http://www.scopus.com/inward/record.url?scp=80052399091&partnerID=8YFLogxK

U2 - 10.1186/scrt46

DO - 10.1186/scrt46

M3 - Review article

C2 - 21345255

AN - SCOPUS:80052399091

SN - 1757-6512

VL - 2

JO - Stem Cell Research and Therapy

JF - Stem Cell Research and Therapy

IS - 1

M1 - 5

ER -

Cell fate conversion by mRNA

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this