Cellular uptake studies with β-peptides

Magnus Rueping; Yogesh Mahajan; Markus Sauer; Dieter Seebach

doi:10.1002/1439-7633(20020301)3:2/3<257::AID-CBIC257>3.0.CO;2-S

Cellular uptake studies with β-peptides

Magnus Rueping, Yogesh Mahajan, Markus Sauer, Dieter Seebach^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Translocation across the membrane into cells is possible for certain peptides and proteins. To investigate the structural requirements of β-peptides for this process, a series of fluorescein-labeled β-peptides has been synthesized and their cellular uptake into 3T3 mouse fibroblast cells determined by fluorescence microscopy (see picture). Polycationic β-peptides have been shown to internalize into cells, and accumulation in the cytosol and nucleus is observed.

Original language	English (US)
Pages (from-to)	257-259
Number of pages	3
Journal	ChemBioChem
Volume	3
Issue number	2-3
DOIs	https://doi.org/10.1002/1439-7633(20020301)3:2/3<257::AID-CBIC257>3.0.CO;2-S
State	Published - Mar 1 2002
Externally published	Yes

Keywords

Arginine
Cellular uptake
Fluorescence microscopy
Peptides

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/1439-7633(20020301)3:2/3<257::AID-CBIC257>3.0.CO;2-S

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AU - Sauer, Markus

AU - Seebach, Dieter

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Y1 - 2002/3/1

N2 - Translocation across the membrane into cells is possible for certain peptides and proteins. To investigate the structural requirements of β-peptides for this process, a series of fluorescein-labeled β-peptides has been synthesized and their cellular uptake into 3T3 mouse fibroblast cells determined by fluorescence microscopy (see picture). Polycationic β-peptides have been shown to internalize into cells, and accumulation in the cytosol and nucleus is observed.

AB - Translocation across the membrane into cells is possible for certain peptides and proteins. To investigate the structural requirements of β-peptides for this process, a series of fluorescein-labeled β-peptides has been synthesized and their cellular uptake into 3T3 mouse fibroblast cells determined by fluorescence microscopy (see picture). Polycationic β-peptides have been shown to internalize into cells, and accumulation in the cytosol and nucleus is observed.

KW - Arginine

KW - Cellular uptake

KW - Fluorescence microscopy

KW - Peptides

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IS - 2-3

ER -

Cellular uptake studies with β-peptides

Abstract

Keywords

ASJC Scopus subject areas

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