TY - JOUR
T1 - Chemoselective Hydroboration of Propargylic Alcohols and Amines Using a Manganese(II) Catalyst
AU - Brzozowska, Aleksandra
AU - Zubar, Viktoriia
AU - Ganardi, Ruth-Christine
AU - Rueping, Magnus
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Dr. O. El-Sepelgy for helpful discussions.
PY - 2020/3/31
Y1 - 2020/3/31
N2 - The first manganese-catalyzed hydroboration of propargylic alcohols and amines as well as internal alkynes is reported. High regio- and stereoselectivity is achieved by applying 2 mol % of a manganese precatalyst based on the readily accessible bis(imino)pyridine ligand and MnCl2 as metal source. Propargylic alcohols and amines, as well as alcohols/amines and symmetric internal alkynes, were efficiently converted into the corresponding functionalized alkenes, which can serve as important and valuable intermediates for further synthetic applications such as cross-coupling reactions.
AB - The first manganese-catalyzed hydroboration of propargylic alcohols and amines as well as internal alkynes is reported. High regio- and stereoselectivity is achieved by applying 2 mol % of a manganese precatalyst based on the readily accessible bis(imino)pyridine ligand and MnCl2 as metal source. Propargylic alcohols and amines, as well as alcohols/amines and symmetric internal alkynes, were efficiently converted into the corresponding functionalized alkenes, which can serve as important and valuable intermediates for further synthetic applications such as cross-coupling reactions.
UR - http://hdl.handle.net/10754/662412
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.0c00941
UR - http://www.scopus.com/inward/record.url?scp=85082872237&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.0c00941
DO - 10.1021/acs.orglett.0c00941
M3 - Article
C2 - 32227972
SN - 1523-7060
JO - Organic Letters
JF - Organic Letters
ER -