Chemotherapy with si-RNA and Anti-Cancer Drugs

Kamaljeet Kaur, Goutam Rath, Saket Chandra, Ranjit Singh, Amit Kumar Goyal

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

BACKGROUND: To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agent exhibits multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene. It is a well known fact that intake of more drugs can lead to cancer chemo resistance, thus siRNA based therapeutic approach is under scrutiny to cure cancer.
Original languageEnglish (US)
Pages (from-to)300-311
Number of pages12
JournalCurrent Drug Delivery
Volume15
Issue number3
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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