Chemotherapy with si-RNA and Anti-Cancer Drugs

Kamaljeet Kaur; Goutam Rath; Saket Chandra; Ranjit Singh; Amit Kumar Goyal

doi:10.2174/1567201814666170518141440

Chemotherapy with si-RNA and Anti-Cancer Drugs

Kamaljeet Kaur, Goutam Rath, Saket Chandra, Ranjit Singh, Amit Kumar Goyal

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

BACKGROUND: To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agent exhibits multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene. It is a well known fact that intake of more drugs can lead to cancer chemo resistance, thus siRNA based therapeutic approach is under scrutiny to cure cancer.

Original language	English (US)
Pages (from-to)	300-311
Number of pages	12
Journal	Current Drug Delivery
Volume	15
Issue number	3
DOIs	https://doi.org/10.2174/1567201814666170518141440
State	Published - Jan 1 2018
Externally published	Yes

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10.2174/1567201814666170518141440

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AU - Rath, Goutam

AU - Chandra, Saket

AU - Singh, Ranjit

AU - Goyal, Amit Kumar

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AB - BACKGROUND: To treat cancer, chemotherapy is a key therapeutic approach which is associated with several limitations. This chemotherapeutical agent exhibits multi drug resistance coupled with undesirable side effects. This multidrug resistance is exhibited by tumor cell due to actuation of drug out flow mechanism, programmed cell death and protection mechanisms etc. One of the therapeutic approaches to cure cancer is RNA interference (RNAi). Small interfering RNA (si-RNA) is considered as a major therapeutic tool used to control expression of a particular gene. It is a well known fact that intake of more drugs can lead to cancer chemo resistance, thus siRNA based therapeutic approach is under scrutiny to cure cancer.

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Chemotherapy with si-RNA and Anti-Cancer Drugs

Abstract

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