TY - JOUR
T1 - Chiral AuI
- and AuIII
-Isothiourea Complexes: Synthesis, Characterization and Application
AU - Gasperini, Danila
AU - Greenhalgh, Mark D.
AU - Imad, Rehan
AU - Siddiqui, Shezaib
AU - Malik, Anum
AU - Arshad, Fizza
AU - Choudhary, Muhammad Iqbal
AU - Al-Majid, Abdullah M.
AU - Cordes, David B.
AU - Slawin, Alexandra M. Z.
AU - Nolan, Steven P.
AU - Smith, Andrew D.
N1 - KAUST Repository Item: Exported on 2021-03-11
Acknowledged KAUST grant number(s): OSR-2015-CCF-1974-03
Acknowledgements: A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. S.P.N. thanks King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) and King Saud University for support via its DSFP program.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2018/12/21
Y1 - 2018/12/21
N2 - During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
AB - During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
UR - http://hdl.handle.net/10754/668045
UR - http://doi.wiley.com/10.1002/chem.201804653
UR - http://www.scopus.com/inward/record.url?scp=85059011049&partnerID=8YFLogxK
U2 - 10.1002/chem.201804653
DO - 10.1002/chem.201804653
M3 - Article
SN - 0947-6539
VL - 25
SP - 1064
EP - 1075
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 4
ER -
