Circadian blueprint of metabolic pathways in the brain

Carolina Magdalen Greco, Paolo Sassone–Corsi

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.
Original languageEnglish (US)
Pages (from-to)71-82
Number of pages12
JournalNature Reviews Neuroscience
Issue number2
StatePublished - Dec 17 2018
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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