Coatomer-dependent protein delivery to lipid droplets

Krishnakant G. Soni, Gonzalo A. Mardones, Rachid Sougrat, Elena Smirnova, Catherine L. Jackson*, Juan S. Bonifacino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

202 Scopus citations

Abstract

Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

Original languageEnglish (US)
Pages (from-to)1834-1841
Number of pages8
JournalJournal of Cell Science
Volume122
Issue number11
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • ATGL
  • Lipid droplet
  • Lipid homeostasis

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Coatomer-dependent protein delivery to lipid droplets'. Together they form a unique fingerprint.

Cite this