Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Huaifeng Li; Abdullah Al Dakhil; Daniel Lupp; Sandeep Suryabhan Gholap; Zhiping Lai; Lan-Chang Liang; Kuo-Wei Huang

doi:10.1021/acs.orglett.8b02744

Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Huaifeng Li, Abdullah Al Dakhil, Daniel Lupp, Sandeep Suryabhan Gholap, Zhiping Lai, Lan-Chang Liang, Kuo-Wei Huang

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.

Original language	English (US)
Pages (from-to)	6430-6435
Number of pages	6
Journal	Organic Letters
Volume	20
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.8b02744
State	Published - Oct 19 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.8b02744

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title = "Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines",

abstract = "The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.",

author = "Huaifeng Li and {Al Dakhil}, Abdullah and Daniel Lupp and Gholap, {Sandeep Suryabhan} and Zhiping Lai and Lan-Chang Liang and Kuo-Wei Huang",

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AU - Li, Huaifeng

AU - Al Dakhil, Abdullah

AU - Lupp, Daniel

AU - Gholap, Sandeep Suryabhan

AU - Lai, Zhiping

AU - Liang, Lan-Chang

AU - Huang, Kuo-Wei

PY - 2018/10/19

Y1 - 2018/10/19

N2 - The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.

AB - The first example of cobalt-catalyzed selective hydrogenation of nitriles to secondary imines is reported. The results demonstrate the significantly different selectivity compared with the previously reported cobalt catalytic system during the nitrile hydrogenation. A variety of aromatic and aliphatic nitriles are hydrogenated to the corresponding secondary imines.

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JO - Organic Letters

JF - Organic Letters

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Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Abstract

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CCDC 1859265: Experimental Crystal Structure Determination : dichloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-dicyclopentyl(phosphinous amide)])-cobalt

CCDC 1858909: Experimental Crystal Structure Determination : dichloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-diisopropyl(phosphinous amide)])-cobalt tetrahydrofuran solvate

CCDC 1858908: Experimental Crystal Structure Determination : chloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-di-t-butyl(phosphinous amide)])-cobalt chloride methanol solvate

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Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 1859265: Experimental Crystal Structure Determination : dichloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-dicyclopentyl(phosphinous amide)])-cobalt

CCDC 1858909: Experimental Crystal Structure Determination : dichloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-diisopropyl(phosphinous amide)])-cobalt tetrahydrofuran solvate

CCDC 1858908: Experimental Crystal Structure Determination : chloro-(N,N'-(pyridine-2,6-diyl)bis[P,P-di-t-butyl(phosphinous amide)])-cobalt chloride methanol solvate

Cite this