Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Renaud Jolivet; Igor Allaman; Luc Pellerin; Pierre J. Magistretti; Bruno Weber

doi:10.1038/jcbfm.2010.132

Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Renaud Jolivet^*, Igor Allaman, Luc Pellerin, Pierre J. Magistretti, Bruno Weber

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

72 Scopus citations

Abstract

Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.

Original language	English (US)
Pages (from-to)	1982-1986
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	12
DOIs	https://doi.org/10.1038/jcbfm.2010.132
State	Published - Dec 2010
Externally published	Yes

Keywords

astrocytes
glucose
lactate
mathematical modeling
neuronal-glial interaction

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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abstract = "Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.",

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author = "Renaud Jolivet and Igor Allaman and Luc Pellerin and Magistretti, {Pierre J.} and Bruno Weber",

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T1 - Comment on recent modeling studies of astrocyte-neuron metabolic interactions

AU - Jolivet, Renaud

AU - Allaman, Igor

AU - Pellerin, Luc

AU - Magistretti, Pierre J.

AU - Weber, Bruno

PY - 2010/12

Y1 - 2010/12

N2 - Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.

AB - Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.

KW - astrocytes

KW - glucose

KW - lactate

KW - mathematical modeling

KW - neuronal-glial interaction

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DO - 10.1038/jcbfm.2010.132

M3 - Comment/debate

C2 - 20700131

AN - SCOPUS:78649707991

SN - 0271-678X

VL - 30

SP - 1982

EP - 1986

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 12

ER -

Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Abstract

Keywords

ASJC Scopus subject areas

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