Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment

Jessica L. Clarke; Jeffrey L. Anderson; John F. Carlquist; Richard F. Roberts; Benjamin D. Horne; Tami L. Bair; Matthew J. Kolek; Chrissa P. Mower; Ashle M. Crane; William L. Roberts; Joseph B. Muhlestein

doi:10.1016/j.amjcard.2004.08.087

Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment

Jessica L. Clarke, Jeffrey L. Anderson, John F. Carlquist, Richard F. Roberts, Benjamin D. Horne, Tami L. Bair, Matthew J. Kolek, Chrissa P. Mower, Ashle M. Crane, William L. Roberts, Joseph B. Muhlestein

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A medium-sensitivity assay for C-reactive protein (CRP) was compared with a high-sensitivity, enhanced immunoturbidimetric assay in 803 angiographically studied patients. Different absolute CRP values were found by the assays, but there was a high correlation by quartile rank and similar predictive values for death and myocardial infarction. This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank. © 2005 by Excerpta Medica Inc.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	American Journal of Cardiology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.amjcard.2004.08.087
State	Published - Jan 1 2005
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Clarke, J. L., Anderson, J. L., Carlquist, J. F., Roberts, R. F., Horne, B. D., Bair, T. L., Kolek, M. J., Mower, C. P., Crane, A. M., Roberts, W. L., & Muhlestein, J. B. (2005). Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment. American Journal of Cardiology, 95(1), 155-158. https://doi.org/10.1016/j.amjcard.2004.08.087

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abstract = "A medium-sensitivity assay for C-reactive protein (CRP) was compared with a high-sensitivity, enhanced immunoturbidimetric assay in 803 angiographically studied patients. Different absolute CRP values were found by the assays, but there was a high correlation by quartile rank and similar predictive values for death and myocardial infarction. This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank. {\textcopyright} 2005 by Excerpta Medica Inc.",

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AU - Bair, Tami L.

AU - Kolek, Matthew J.

AU - Mower, Chrissa P.

AU - Crane, Ashle M.

AU - Roberts, William L.

AU - Muhlestein, Joseph B.

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AB - A medium-sensitivity assay for C-reactive protein (CRP) was compared with a high-sensitivity, enhanced immunoturbidimetric assay in 803 angiographically studied patients. Different absolute CRP values were found by the assays, but there was a high correlation by quartile rank and similar predictive values for death and myocardial infarction. This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank. © 2005 by Excerpta Medica Inc.

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Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment

Abstract

ASJC Scopus subject areas

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