TY - JOUR
T1 - Comparison of Nigella sativa and Trachyspermum ammi via experimental investigation and biotechnological potential
AU - Arif, Sadia
AU - Saqib, Hira
AU - Mubashir, Muhammad
AU - Malik, Shaukat Iqbal
AU - Mukhtar, Ahmad
AU - Saqib, Sidra
AU - Ullah, Sami
AU - Show, Pau Loke
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Trachyspermum ammi and Nigella sativa are mostly used as traditional medicinal plants to cure different diseases. It was observed that both extracts showed significant antibacterial activity against gram-negative bacteria and which may be extended to the SARS-CoV-2, leading to the absence of the peptidoglycan layer. T. ammi showed the highest percentage inhibition in the antifungal assay compared to N. sativa against Aspergillus flavus. The antioxidant assay was performed. It was observed that T. ammi has more free radical scavenging activity as indicated by low IC50. The cytotoxic assay was performed by following brine shrimp lethality assay, and it was observed that T. ammi has more cytotoxicity. The results are that both N. sativa and T. ammi are the origins of active pharmaceutical ingredients and have several pharmacological effects. Furthermore, both essential antibacterial agents were identified and can, therefore, be used as an antibiotic. They have now shown important antioxidant and cytotoxic potential, such that their potential in herbal medicine and cancer genetics can now unravel. In the future, the bioactive molecules responsible for biological processes will be separated. Besides, the nano-formulations in nano-biotechnology may also be analyzed with these extracts.
AB - Trachyspermum ammi and Nigella sativa are mostly used as traditional medicinal plants to cure different diseases. It was observed that both extracts showed significant antibacterial activity against gram-negative bacteria and which may be extended to the SARS-CoV-2, leading to the absence of the peptidoglycan layer. T. ammi showed the highest percentage inhibition in the antifungal assay compared to N. sativa against Aspergillus flavus. The antioxidant assay was performed. It was observed that T. ammi has more free radical scavenging activity as indicated by low IC50. The cytotoxic assay was performed by following brine shrimp lethality assay, and it was observed that T. ammi has more cytotoxicity. The results are that both N. sativa and T. ammi are the origins of active pharmaceutical ingredients and have several pharmacological effects. Furthermore, both essential antibacterial agents were identified and can, therefore, be used as an antibiotic. They have now shown important antioxidant and cytotoxic potential, such that their potential in herbal medicine and cancer genetics can now unravel. In the future, the bioactive molecules responsible for biological processes will be separated. Besides, the nano-formulations in nano-biotechnology may also be analyzed with these extracts.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0255270121000179
UR - http://www.scopus.com/inward/record.url?scp=85100383904&partnerID=8YFLogxK
U2 - 10.1016/j.cep.2021.108313
DO - 10.1016/j.cep.2021.108313
M3 - Article
SN - 0255-2701
VL - 161
JO - Chemical Engineering and Processing - Process Intensification
JF - Chemical Engineering and Processing - Process Intensification
ER -
