Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene

K. Shimotohno; Y. Takahashi; N. Shimizu; T. Gojobori; D. W. Golde; I. S. Chen; M. Miwa; T. Sugimura

doi:10.1073/pnas.82.10.3101

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene

K. Shimotohno, Y. Takahashi, N. Shimizu, T. Gojobori, D. W. Golde, I. S. Chen, M. Miwa, T. Sugimura

Research output: Contribution to journal › Article › peer-review

318 Scopus citations

Abstract

The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal reports and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.

Original language	English (US)
Pages (from-to)	3101-3105
Number of pages	5
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	82
Issue number	10
DOIs	https://doi.org/10.1073/pnas.82.10.3101
State	Published - 1985
Externally published	Yes

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Shimotohno, K., Takahashi, Y., Shimizu, N., Gojobori, T., Golde, D. W., Chen, I. S., Miwa, M., & Sugimura, T. (1985). Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 82(10), 3101-3105. https://doi.org/10.1073/pnas.82.10.3101

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title = "Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene",

abstract = "The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal reports and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.",

author = "K. Shimotohno and Y. Takahashi and N. Shimizu and T. Gojobori and Golde, {D. W.} and Chen, {I. S.} and M. Miwa and T. Sugimura",

year = "1985",

doi = "10.1073/pnas.82.10.3101",

language = "English (US)",

volume = "82",

pages = "3101--3105",

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publisher = "National Academy of Sciences",

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}

Shimotohno, K, Takahashi, Y, Shimizu, N, Gojobori, T, Golde, DW, Chen, IS, Miwa, M & Sugimura, T 1985, 'Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 82, no. 10, pp. 3101-3105. https://doi.org/10.1073/pnas.82.10.3101

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene. / Shimotohno, K.; Takahashi, Y.; Shimizu, N. et al.
In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 82, No. 10, 1985, p. 3101-3105.

Research output: Contribution to journal › Article › peer-review

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Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene

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