TY - JOUR
T1 - Computational analysis of candidate disease genes and variants for Salt-sensitive hypertension in indigenous Southern Africans
AU - Tiffin, Nicki
AU - Meintjes, Ayton
AU - Ramesar, Rajkumar
AU - Bajic, Vladimir B.
AU - Rayner, Brian
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2010/9/27
Y1 - 2010/9/27
N2 - Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension. © 2010 Tiffin et al.
AB - Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt sensitivity appears more prevalent in people of indigenous African origin. The underlying genetics of salt-sensitive hypertension, however, are poorly understood. In this study, computational methods including text- and data-mining have been used to select and prioritize candidate aetiological genes for salt-sensitive hypertension. Additionally, we have compared allele frequencies and copy number variation for single nucleotide polymorphisms in candidate genes between indigenous Southern African and Caucasian populations, with the aim of identifying candidate genes with significant variability between the population groups: identifying genetic variability between population groups can exploit ethnic differences in disease prevalence to aid with prioritisation of good candidate genes. Our top-ranking candidate genes include parathyroid hormone precursor (PTH) and type-1angiotensin II receptor (AGTR1). We propose that the candidate genes identified in this study warrant further investigation as potential aetiological genes for salt-sensitive hypertension. © 2010 Tiffin et al.
UR - http://hdl.handle.net/10754/325286
UR - https://dx.plos.org/10.1371/journal.pone.0012989
UR - http://www.scopus.com/inward/record.url?scp=77958558370&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0012989
DO - 10.1371/journal.pone.0012989
M3 - Article
C2 - 20886000
SN - 1932-6203
VL - 5
SP - e12989
JO - PLoS ONE
JF - PLoS ONE
IS - 9
ER -