Concealing cellular defects in pluripotent stem cells

Weiqi Zhang; Jing Qu; Keiichiro Suzuki; Guang Hui Liu; Juan Carlos Izpisua Belmonte

doi:10.1016/j.tcb.2013.07.001

Concealing cellular defects in pluripotent stem cells

Weiqi Zhang, Jing Qu, Keiichiro Suzuki, Guang Hui Liu^*, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies.

Original language	English (US)
Pages (from-to)	587-592
Number of pages	6
Journal	Trends in Cell Biology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.tcb.2013.07.001
State	Published - Dec 2013
Externally published	Yes

Keywords

Disease modeling
Pluripotent stem cell
Reprogramming

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2013.07.001

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@article{4b213e7977004258a7771d2888a994ac,

title = "Concealing cellular defects in pluripotent stem cells",

abstract = "Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies.",

keywords = "Disease modeling, Pluripotent stem cell, Reprogramming",

author = "Weiqi Zhang and Jing Qu and Keiichiro Suzuki and Liu, {Guang Hui} and Belmonte, {Juan Carlos Izpisua}",

note = "Funding Information: We apologize to those works that could not be cited owing to space constraints. We are grateful to M. Schwarz and A. Goebl for critical reading of the manuscript. G.H.L. is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), National Natural Science Foundation of China (NSFC) (81271266, 31222039, 31201111), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (2013kf05, 2013kf11), and State Key Laboratory of Drug Research (SIMM1302KF-17). K.S. is supported by a California Institute for Regenerative Medicine (CIRM) fellowship. J.C.I.B. was supported by TERCEL-ISCIII-MINECO, CIBER, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, Sanofi, The Leona M. and Harry B. Helmsley Charitable Trust, and The Ellison Medical Foundation.",

year = "2013",

month = dec,

doi = "10.1016/j.tcb.2013.07.001",

language = "English (US)",

volume = "23",

pages = "587--592",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd",

number = "12",

}

TY - JOUR

T1 - Concealing cellular defects in pluripotent stem cells

AU - Zhang, Weiqi

AU - Qu, Jing

AU - Suzuki, Keiichiro

AU - Liu, Guang Hui

AU - Belmonte, Juan Carlos Izpisua

N1 - Funding Information: We apologize to those works that could not be cited owing to space constraints. We are grateful to M. Schwarz and A. Goebl for critical reading of the manuscript. G.H.L. is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), National Natural Science Foundation of China (NSFC) (81271266, 31222039, 31201111), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (2013kf05, 2013kf11), and State Key Laboratory of Drug Research (SIMM1302KF-17). K.S. is supported by a California Institute for Regenerative Medicine (CIRM) fellowship. J.C.I.B. was supported by TERCEL-ISCIII-MINECO, CIBER, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, Sanofi, The Leona M. and Harry B. Helmsley Charitable Trust, and The Ellison Medical Foundation.

PY - 2013/12

Y1 - 2013/12

N2 - Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies.

AB - Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies.

KW - Disease modeling

KW - Pluripotent stem cell

KW - Reprogramming

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AN - SCOPUS:84888200046

SN - 0962-8924

VL - 23

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JO - Trends in Cell Biology

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ER -

Concealing cellular defects in pluripotent stem cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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