Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Hanan Hamamy; Stylianos E. Antonarakis; Luigi Luca Cavalli-Sforza; Samia Temtamy; Giovanni Romeo; Leo P.Ten Kate; Robin L. Bennett; Alison Shaw; Andre Megarbane; Cornelia Van Duijn; Heli Bathija; Siv Fokstuen; Eric Engel; Joel Zlotogora; Emmanouil Dermitzakis; Armand Bottani; Sophie Dahoun; Michael A. Morris; Steve Arsenault; Mona S. Aglan; Mubasshir Ajaz; Ayad Alkalamchi; Dhekra Alnaqeb; Mohamed K. Alwasiyah; Nawfal Anwer; Rawan Awwad; Melissa Bonnefin; Peter Corry; Lorraine Gwanmesia; Gulshan A. Karbani; Maryam Mostafavi; Tommaso Pippucci; Emmanuelle Ranza-Boscardin; Bruno Reversade; Saghira M. Sharif; Marieke E. Teeuw; Alan H. Bittles

doi:10.1097/GIM.0b013e318217477f

Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Hanan Hamamy, Stylianos E. Antonarakis, Luigi Luca Cavalli-Sforza, Samia Temtamy, Giovanni Romeo, Leo P.Ten Kate, Robin L. Bennett, Alison Shaw, Andre Megarbane, Cornelia Van Duijn, Heli Bathija, Siv Fokstuen, Eric Engel, Joel Zlotogora, Emmanouil Dermitzakis, Armand Bottani, Sophie Dahoun, Michael A. Morris, Steve Arsenault, Mona S. AglanMubasshir Ajaz, Ayad Alkalamchi, Dhekra Alnaqeb, Mohamed K. Alwasiyah, Nawfal Anwer, Rawan Awwad, Melissa Bonnefin, Peter Corry, Lorraine Gwanmesia, Gulshan A. Karbani, Maryam Mostafavi, Tommaso Pippucci, Emmanuelle Ranza-Boscardin, Bruno Reversade, Saghira M. Sharif, Marieke E. Teeuw, Alan H. Bittles

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

230 Scopus citations

Abstract

Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. © 2011 Lippincott Williams &Wilkins.

Original language	English (US)
Title of host publication	Genetics in Medicine
Pages	841-847
Number of pages	7
DOIs	https://doi.org/10.1097/GIM.0b013e318217477f
State	Published - Sep 1 2011
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/GIM.0b013e318217477f

Cite this

Hamamy, H., Antonarakis, S. E., Cavalli-Sforza, L. L., Temtamy, S., Romeo, G., Kate, L. P. T., Bennett, R. L., Shaw, A., Megarbane, A., Van Duijn, C., Bathija, H., Fokstuen, S., Engel, E., Zlotogora, J., Dermitzakis, E., Bottani, A., Dahoun, S., Morris, M. A., Arsenault, S., ... Bittles, A. H. (2011). Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report. In Genetics in Medicine (pp. 841-847) https://doi.org/10.1097/GIM.0b013e318217477f

@inproceedings{7b94bbda35444b9b836fe50dc04b7e66,

title = "Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report",

abstract = "Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. {\textcopyright} 2011 Lippincott Williams &Wilkins.",

author = "Hanan Hamamy and Antonarakis, {Stylianos E.} and Cavalli-Sforza, {Luigi Luca} and Samia Temtamy and Giovanni Romeo and Kate, {Leo P.Ten} and Bennett, {Robin L.} and Alison Shaw and Andre Megarbane and {Van Duijn}, Cornelia and Heli Bathija and Siv Fokstuen and Eric Engel and Joel Zlotogora and Emmanouil Dermitzakis and Armand Bottani and Sophie Dahoun and Morris, {Michael A.} and Steve Arsenault and Aglan, {Mona S.} and Mubasshir Ajaz and Ayad Alkalamchi and Dhekra Alnaqeb and Alwasiyah, {Mohamed K.} and Nawfal Anwer and Rawan Awwad and Melissa Bonnefin and Peter Corry and Lorraine Gwanmesia and Karbani, {Gulshan A.} and Maryam Mostafavi and Tommaso Pippucci and Emmanuelle Ranza-Boscardin and Bruno Reversade and Sharif, {Saghira M.} and Teeuw, {Marieke E.} and Bittles, {Alan H.}",

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doi = "10.1097/GIM.0b013e318217477f",

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Hamamy, H, Antonarakis, SE, Cavalli-Sforza, LL, Temtamy, S, Romeo, G, Kate, LPT, Bennett, RL, Shaw, A, Megarbane, A, Van Duijn, C, Bathija, H, Fokstuen, S, Engel, E, Zlotogora, J, Dermitzakis, E, Bottani, A, Dahoun, S, Morris, MA, Arsenault, S, Aglan, MS, Ajaz, M, Alkalamchi, A, Alnaqeb, D, Alwasiyah, MK, Anwer, N, Awwad, R, Bonnefin, M, Corry, P, Gwanmesia, L, Karbani, GA, Mostafavi, M, Pippucci, T, Ranza-Boscardin, E, Reversade, B, Sharif, SM, Teeuw, ME & Bittles, AH 2011, Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report. in Genetics in Medicine. pp. 841-847. https://doi.org/10.1097/GIM.0b013e318217477f

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AU - Hamamy, Hanan

AU - Antonarakis, Stylianos E.

AU - Cavalli-Sforza, Luigi Luca

AU - Temtamy, Samia

AU - Romeo, Giovanni

AU - Kate, Leo P.Ten

AU - Bennett, Robin L.

AU - Shaw, Alison

AU - Megarbane, Andre

AU - Van Duijn, Cornelia

AU - Bathija, Heli

AU - Fokstuen, Siv

AU - Engel, Eric

AU - Zlotogora, Joel

AU - Dermitzakis, Emmanouil

AU - Bottani, Armand

AU - Dahoun, Sophie

AU - Morris, Michael A.

AU - Arsenault, Steve

AU - Aglan, Mona S.

AU - Ajaz, Mubasshir

AU - Alkalamchi, Ayad

AU - Alnaqeb, Dhekra

AU - Alwasiyah, Mohamed K.

AU - Anwer, Nawfal

AU - Awwad, Rawan

AU - Bonnefin, Melissa

AU - Corry, Peter

AU - Gwanmesia, Lorraine

AU - Karbani, Gulshan A.

AU - Mostafavi, Maryam

AU - Pippucci, Tommaso

AU - Ranza-Boscardin, Emmanuelle

AU - Reversade, Bruno

AU - Sharif, Saghira M.

AU - Teeuw, Marieke E.

AU - Bittles, Alan H.

N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. © 2011 Lippincott Williams &Wilkins.

AB - Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies. © 2011 Lippincott Williams &Wilkins.

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U2 - 10.1097/GIM.0b013e318217477f

DO - 10.1097/GIM.0b013e318217477f

M3 - Conference contribution

SP - 841

EP - 847

BT - Genetics in Medicine

ER -

Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Abstract

ASJC Scopus subject areas

UN SDGs

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