Continuous-flow hydration-condensation reaction: Synthesis of αβ-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Magnus Rueping; Teerawut Bootwicha; Hannah Baars; Erli Sugiono

doi:10.3762/bjoc.7.198

Continuous-flow hydration-condensation reaction: Synthesis of αβ-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Magnus Rueping^*, Teerawut Bootwicha, Hannah Baars, Erli Sugiono

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.

Original language	English (US)
Pages (from-to)	1680-1687
Number of pages	8
Journal	Beilstein journal of organic chemistry
Volume	7
DOIs	https://doi.org/10.3762/bjoc.7.198
State	Published - Dec 15 2011
Externally published	Yes

Keywords

Chalcones
Flow reactor
Green chemistry
Heterogeneous catalysis, microwave

ASJC Scopus subject areas

Organic Chemistry

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10.3762/bjoc.7.198

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abstract = "A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.",

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author = "Magnus Rueping and Teerawut Bootwicha and Hannah Baars and Erli Sugiono",

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AU - Rueping, Magnus

AU - Bootwicha, Teerawut

AU - Baars, Hannah

AU - Sugiono, Erli

PY - 2011/12/15

Y1 - 2011/12/15

N2 - A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.

AB - A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale.

KW - Chalcones

KW - Flow reactor

KW - Green chemistry

KW - Heterogeneous catalysis, microwave

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DO - 10.3762/bjoc.7.198

M3 - Article

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AN - SCOPUS:84455199887

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JF - Beilstein journal of organic chemistry

ER -

Continuous-flow hydration-condensation reaction: Synthesis of αβ-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Abstract

Keywords

ASJC Scopus subject areas

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