TY - JOUR
T1 - Contribution of genetic polymorphisms on functional status at very old age: A gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway
AU - Dato, S.
AU - Soerensen, M.
AU - Lagani, V.
AU - Montesanto, A.
AU - Passarino, G.
AU - Christensen, K.
AU - Tan, Q.
AU - Christiansen, L.
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-23
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring with aging is the imbalance between production and accumulation of oxidative damage to macromolecules, together with a decreased efficiency of stress response to avoid or repair such damage. In this paper we investigated the association of 38 genes (311 SNPs) belonging to the pro-antioxidant pathways with physical and cognitive performances, by analyzing single SNP and gene-based associations with Hand Grip strength (HG), Activities of Daily Living (ADL), Walking Speed (WS), Mini Mental State Examination (MMSE) and Composite Cognitive Score (CCS) in a Cohort of 1089 Danish nonagenarians. Moreover, for each gene analyzed in the pro-antioxidant pathway, we tested the influence on longitudinal survival.In the whole sample, nominal associations were found for TXNRD1 variability with ADL and WS, NDUFS1 and UCP3 with HG and WS, GCLC and UCP2 with WS (p.
AB - Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring with aging is the imbalance between production and accumulation of oxidative damage to macromolecules, together with a decreased efficiency of stress response to avoid or repair such damage. In this paper we investigated the association of 38 genes (311 SNPs) belonging to the pro-antioxidant pathways with physical and cognitive performances, by analyzing single SNP and gene-based associations with Hand Grip strength (HG), Activities of Daily Living (ADL), Walking Speed (WS), Mini Mental State Examination (MMSE) and Composite Cognitive Score (CCS) in a Cohort of 1089 Danish nonagenarians. Moreover, for each gene analyzed in the pro-antioxidant pathway, we tested the influence on longitudinal survival.In the whole sample, nominal associations were found for TXNRD1 variability with ADL and WS, NDUFS1 and UCP3 with HG and WS, GCLC and UCP2 with WS (p.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0531556514000266
UR - http://www.scopus.com/inward/record.url?scp=84893371194&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2014.01.014
DO - 10.1016/j.exger.2014.01.014
M3 - Article
SN - 0531-5565
VL - 52
SP - 23
EP - 29
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -