Controllable Microdroplet Splitting via Additional Lateral Flow and its Application in Rapid Synthesis of Multi-scale Microspheres

Bingpu Zhou; Cong Wang; Xiao Xiao; Yu Sanna Hui; Yulin Cao; Weijia Wen

doi:10.1039/c4ra15552a

Controllable Microdroplet Splitting via Additional Lateral Flow and its Application in Rapid Synthesis of Multi-scale Microspheres

Bingpu Zhou, Cong Wang, Xiao Xiao, Yu Sanna Hui, Yulin Cao, Weijia Wen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In this paper, we demonstrate that controllable microdroplet splitting could be obtained via additional lateral flow with simplicity and high controllability. The volume ratio of the two splitting products can be flexibly regulated by adjusting the flow rate ratio between the main and additional lateral flows. The splitting phenomena under different main flow rates were investigated. A volume ratio up to 200 : 1 of the two daughter droplets under a relatively higher main flow rate was experimentally achieved based on our approach. In this case, we have successfully achieved uniform daughter droplets with a smallest diameter of ∼19.5 ± 1.6 μm. With such a design, we have synthesized uniform PEGDA hydrogel microspheres with diameters ranging from ∼30 μm to over hundred of micrometers simultaneously.

Original language	English (US)
Pages (from-to)	10365-10371
Number of pages	7
Journal	RSC Adv.
Volume	5
Issue number	14
DOIs	https://doi.org/10.1039/c4ra15552a
State	Published - 2015
Externally published	Yes

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title = "Controllable Microdroplet Splitting via Additional Lateral Flow and its Application in Rapid Synthesis of Multi-scale Microspheres",

abstract = "In this paper, we demonstrate that controllable microdroplet splitting could be obtained via additional lateral flow with simplicity and high controllability. The volume ratio of the two splitting products can be flexibly regulated by adjusting the flow rate ratio between the main and additional lateral flows. The splitting phenomena under different main flow rates were investigated. A volume ratio up to 200 : 1 of the two daughter droplets under a relatively higher main flow rate was experimentally achieved based on our approach. In this case, we have successfully achieved uniform daughter droplets with a smallest diameter of ∼19.5 ± 1.6 μm. With such a design, we have synthesized uniform PEGDA hydrogel microspheres with diameters ranging from ∼30 μm to over hundred of micrometers simultaneously.",

author = "Bingpu Zhou and Cong Wang and Xiao Xiao and Hui, {Yu Sanna} and Yulin Cao and Weijia Wen",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors would like to acknowledge the support by Hong Kong RGC grant HKUST 605411 and NSFC/RGC joint grant N_HKUST601/11. The work was also partially supported by the Nanoscience and Nanotechnology Program at HKUST. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2015",

doi = "10.1039/c4ra15552a",

language = "English (US)",

volume = "5",

pages = "10365--10371",

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publisher = "Royal Society of Chemistry",

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T1 - Controllable Microdroplet Splitting via Additional Lateral Flow and its Application in Rapid Synthesis of Multi-scale Microspheres

AU - Zhou, Bingpu

AU - Wang, Cong

AU - Xiao, Xiao

AU - Hui, Yu Sanna

AU - Cao, Yulin

AU - Wen, Weijia

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors would like to acknowledge the support by Hong Kong RGC grant HKUST 605411 and NSFC/RGC joint grant N_HKUST601/11. The work was also partially supported by the Nanoscience and Nanotechnology Program at HKUST. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2015

Y1 - 2015

N2 - In this paper, we demonstrate that controllable microdroplet splitting could be obtained via additional lateral flow with simplicity and high controllability. The volume ratio of the two splitting products can be flexibly regulated by adjusting the flow rate ratio between the main and additional lateral flows. The splitting phenomena under different main flow rates were investigated. A volume ratio up to 200 : 1 of the two daughter droplets under a relatively higher main flow rate was experimentally achieved based on our approach. In this case, we have successfully achieved uniform daughter droplets with a smallest diameter of ∼19.5 ± 1.6 μm. With such a design, we have synthesized uniform PEGDA hydrogel microspheres with diameters ranging from ∼30 μm to over hundred of micrometers simultaneously.

AB - In this paper, we demonstrate that controllable microdroplet splitting could be obtained via additional lateral flow with simplicity and high controllability. The volume ratio of the two splitting products can be flexibly regulated by adjusting the flow rate ratio between the main and additional lateral flows. The splitting phenomena under different main flow rates were investigated. A volume ratio up to 200 : 1 of the two daughter droplets under a relatively higher main flow rate was experimentally achieved based on our approach. In this case, we have successfully achieved uniform daughter droplets with a smallest diameter of ∼19.5 ± 1.6 μm. With such a design, we have synthesized uniform PEGDA hydrogel microspheres with diameters ranging from ∼30 μm to over hundred of micrometers simultaneously.

UR - http://hdl.handle.net/10754/600246

UR - http://xlink.rsc.org/?DOI=C4RA15552A

UR - http://www.scopus.com/inward/record.url?scp=84921627669&partnerID=8YFLogxK

U2 - 10.1039/c4ra15552a

DO - 10.1039/c4ra15552a

M3 - Article

SN - 2046-2069

VL - 5

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EP - 10371

JO - RSC Adv.

JF - RSC Adv.

IS - 14

ER -

Controllable Microdroplet Splitting via Additional Lateral Flow and its Application in Rapid Synthesis of Multi-scale Microspheres

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