Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation

Stefania Pagliari; Ana Cristina Vilela-Silva; Giancarlo Forte; Francesca Pagliari; Corrado Mandoli; Giovanni Vozzi; Stefano Pietronave; Maria Prat; Silvia Licoccia; Arti Ahluwalia; Enrico Traversa; Marilena Minieri; Paolo Di Nardo

doi:10.1002/adma.201003479

Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation

Stefania Pagliari, Ana Cristina Vilela-Silva, Giancarlo Forte, Francesca Pagliari, Corrado Mandoli, Giovanni Vozzi, Stefano Pietronave, Maria Prat, Silvia Licoccia, Arti Ahluwalia, Enrico Traversa^*, Marilena Minieri, Paolo Di Nardo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.

Original language	English (US)
Pages (from-to)	514-518
Number of pages	5
Journal	Advanced Materials
Volume	23
Issue number	4
DOIs	https://doi.org/10.1002/adma.201003479
State	Published - Jan 25 2011
Externally published	Yes

Keywords

3D scaffold
cardiac progenitor cells
cardiac tissue engineering

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201003479

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title = "Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation",

abstract = "Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.",

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T1 - Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation

AU - Pagliari, Stefania

AU - Vilela-Silva, Ana Cristina

AU - Forte, Giancarlo

AU - Pagliari, Francesca

AU - Mandoli, Corrado

AU - Vozzi, Giovanni

AU - Pietronave, Stefano

AU - Prat, Maria

AU - Licoccia, Silvia

AU - Ahluwalia, Arti

AU - Traversa, Enrico

AU - Minieri, Marilena

AU - Di Nardo, Paolo

PY - 2011/1/25

Y1 - 2011/1/25

N2 - Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.

AB - Three-dimensional cardiac tissue-specific scaffolds made of poly-lactic acid (PLA) have an ordered array of square pores reproducing anisotropic cardiac-like stiffness. The mechano-physical features of the scaffolds favor cardiomyocyte adhesion and survival and combined with biological signals released by neonatal cardiomyocytes can accelerate cardiac stem cell differentiation by emulating in vitro cardiac niche.

KW - 3D scaffold

KW - cardiac progenitor cells

KW - cardiac tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=79251526872&partnerID=8YFLogxK

U2 - 10.1002/adma.201003479

DO - 10.1002/adma.201003479

M3 - Article

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SN - 0935-9648

VL - 23

SP - 514

EP - 518

JO - Advanced Materials

JF - Advanced Materials

IS - 4

ER -

Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation

Abstract

Keywords

ASJC Scopus subject areas

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