Dedifferentiation, transdifferentiation, and reprogramming: Future directions in regenerative medicine

Cristina Eguizabal, Nuria Montserrat, Anna Veiga, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


The main goal of regenerative medicine is to replace damaged tissue. To do this it is necessary to understand in detail the whole regeneration process including differentiated cells that can be converted into progenitor cells (dedifferentiation), cells that can switch into another cell type (transdifferentiation), and somatic cells that can be induced to become pluripotent cells (reprogramming). By studying the regenerative processes in both nonmammal and mammal models, natural or artificial processes could underscore the molecular and cellular mechanisms behind these phenomena and be used to create future regenerative strategies for humans.

Original languageEnglish (US)
Pages (from-to)82-94
Number of pages13
JournalSeminars in Reproductive Medicine
Issue number1
StatePublished - Jan 22 2013


  • dedifferentiation
  • regenerative medicine
  • reprogramming
  • stem cells
  • transdifferentiation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)


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