Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

Shyam M. Rele; Wanxing Cui; Lianchun Wang; Sijian Hou; Ginger Barr-Zarse; Daniel Tatton; Yves Gnanou; Jeffrey D. Esko; Elliot L. Chaikof

doi:10.1021/ja0511974

Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

Shyam M. Rele^*, Wanxing Cui, Lianchun Wang, Sijian Hou, Ginger Barr-Zarse, Daniel Tatton, Yves Gnanou, Jeffrey D. Esko, Elliot L. Chaikof

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 10³-fold greater activity than other multivalent sLe^x glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

Original language	English (US)
Pages (from-to)	10132-10133
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	29
DOIs	https://doi.org/10.1021/ja0511974
State	Published - Jul 27 2005
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties",

abstract = "A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.",

author = "Rele, {Shyam M.} and Wanxing Cui and Lianchun Wang and Sijian Hou and Ginger Barr-Zarse and Daniel Tatton and Yves Gnanou and Esko, {Jeffrey D.} and Chaikof, {Elliot L.}",

year = "2005",

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doi = "10.1021/ja0511974",

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T1 - Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

AU - Rele, Shyam M.

AU - Cui, Wanxing

AU - Wang, Lianchun

AU - Hou, Sijian

AU - Barr-Zarse, Ginger

AU - Tatton, Daniel

AU - Gnanou, Yves

AU - Esko, Jeffrey D.

AU - Chaikof, Elliot L.

PY - 2005/7/27

Y1 - 2005/7/27

N2 - A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

AB - A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

UR - http://www.scopus.com/inward/record.url?scp=22944488021&partnerID=8YFLogxK

U2 - 10.1021/ja0511974

DO - 10.1021/ja0511974

M3 - Article

C2 - 16028900

AN - SCOPUS:22944488021

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SP - 10132

EP - 10133

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 29

ER -

Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

Abstract

ASJC Scopus subject areas

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