Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers

Norased Nasongkia; Bo Chen; Nichole Macaraeg; Megan E. Fox; Jean M.J. Fréchet; Francis C. Szoka

doi:10.1021/ja900062u

Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers

Norased Nasongkia^*, Bo Chen, Nichole Macaraeg, Megan E. Fox, Jean M.J. Fréchet, Francis C. Szoka

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Abstract

The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.

Original language	English (US)
Pages (from-to)	3842-3843
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	11
DOIs	https://doi.org/10.1021/ja900062u
State	Published - Mar 25 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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AU - Chen, Bo

AU - Macaraeg, Nichole

AU - Fox, Megan E.

AU - Fréchet, Jean M.J.

AU - Szoka, Francis C.

PY - 2009/3/25

Y1 - 2009/3/25

N2 - The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.

AB - The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.

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Dependence of pharmacokinetics and biodistribution on polymer architecture: Effect of cyclic versus Linear polymers

Abstract

ASJC Scopus subject areas

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