Designing dendrimers for drug delivery

Mingjun Liu; Jean M.J. Fréchet

doi:10.1016/S1461-5347(99)00203-5

Designing dendrimers for drug delivery

Mingjun Liu, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

473 Scopus citations

Abstract

Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	393-401
Number of pages	9
Journal	Pharmaceutical Science and Technology Today
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/S1461-5347(99)00203-5
State	Published - Oct 1 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmaceutical Science

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title = "Designing dendrimers for drug delivery",

abstract = "Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.",

author = "Mingjun Liu and Fr{\'e}chet, {Jean M.J.}",

note = "Funding Information: We thank our valued collaborator Professor F.C. Szoka (University of California, San Francisco, CA, USA) for stimulating discussions, and Professor R. Duncan (University of London, UK) for sharing unpublished results. Financial support by the National Science Foundation (DMR 9816166) is gratefully acknowledged. ",

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doi = "10.1016/S1461-5347(99)00203-5",

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AU - Fréchet, Jean M.J.

N1 - Funding Information: We thank our valued collaborator Professor F.C. Szoka (University of California, San Francisco, CA, USA) for stimulating discussions, and Professor R. Duncan (University of London, UK) for sharing unpublished results. Financial support by the National Science Foundation (DMR 9816166) is gratefully acknowledged.

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.

AB - Dendrimers are highly branched three-dimensional macromolecules with highly controlled structures, a single molecular weight, a large number of controllable 'peripheral' functionalities and a tendency to adopt a globular shape once a certain size is reached. These features have made their application in pharmaceutical and medicinal chemistry particularly attractive. This review briefly discusses the preparation of dendrimers, their use as gene delivery agents and magnetic resonance imaging agents, and their potential for applications in drug delivery. Copyright (C) 1999 Elsevier Science Ltd.

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DO - 10.1016/S1461-5347(99)00203-5

M3 - Review article

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SP - 393

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JO - Pharmaceutical Science and Technology Today

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IS - 10

ER -

Designing dendrimers for drug delivery

Abstract

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