Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode

Akilarasan Muthumariappan, Mani Govindasamy, Shen Ming Chen, Kogularasu Sakthivel, Veerappan Mani, Tse Wei Chen, Shanthi Selvaraj

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.
Original languageEnglish (US)
Pages (from-to)7446-7456
Number of pages11
JournalInternational Journal of Electrochemical Science
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Electrochemistry

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