Deterministic simulation of growth factor-induced angiogenesis

A continuous and deterministic approach for tissue angiogenesis was implemented and the preliminary results on its application to the simulation of a tumor-induced angiogenesis were described. It was observed that the chromatic growth factors (CGF) is released from both the extracellular matrix (ECM) and the tumor cells, but substantially dominated by the later. The simulation produces capillary networks with realistic structures and morphologies. Results show that at the initial stages of angiogenesis where the capillaries are far from the tumor, all capillaries extend to the right, with the central one proliferating fastest among all.