TY - JOUR
T1 - Development and characterization of nano-fiber patch for the treatment of glaucoma
AU - Gagandeep, null
AU - Garg, Tarun
AU - Malik, Basant
AU - Rath, Goutam
AU - Goyal, Amit K.
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2014/3/12
Y1 - 2014/3/12
N2 - In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.
AB - In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. © 2013 Elsevier B.V. All rights reserved.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0928098713004557
UR - http://www.scopus.com/inward/record.url?scp=84891595696&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2013.11.016
DO - 10.1016/j.ejps.2013.11.016
M3 - Article
SN - 0928-0987
VL - 53
SP - 10
EP - 16
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
IS - 1
ER -