Development and characterization of rifampicin loaded floating microspheres

Pankaj Goyal, S. Gill, U. D. Gupta, Goutam Rath, Raj K. Narang, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.
Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Issue number5
StatePublished - Oct 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology


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