Development and characterization of rifampicin loaded floating microspheres

Pankaj Goyal; S. Gill; U. D. Gupta; Goutam Rath; Raj K. Narang; Amit K. Goyal

doi:10.3109/10731199.2011.573482

Development and characterization of rifampicin loaded floating microspheres

Pankaj Goyal, S. Gill, U. D. Gupta, Goutam Rath, Raj K. Narang, Amit K. Goyal

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Artificial Cells, Blood Substitutes, and Biotechnology
Volume	39
Issue number	5
DOIs	https://doi.org/10.3109/10731199.2011.573482
State	Published - Oct 1 2011
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering
Biotechnology

Access to Document

10.3109/10731199.2011.573482

Cite this

@article{b71a58eb3503473eb1b5b4b1835ac57b,

title = "Development and characterization of rifampicin loaded floating microspheres",

abstract = "Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. {\textcopyright} 2011 Informa Healthcare USA, Inc.",

author = "Pankaj Goyal and S. Gill and Gupta, {U. D.} and Goutam Rath and Narang, {Raj K.} and Goyal, {Amit K.}",

note = "Generated from Scopus record by KAUST IRTS on 2023-10-12",

year = "2011",

month = oct,

day = "1",

doi = "10.3109/10731199.2011.573482",

language = "English (US)",

volume = "39",

pages = "330--334",

journal = "Artificial Cells, Blood Substitutes, and Biotechnology",

issn = "1073-1199",

publisher = "Informa Healthcare",

number = "5",

}

TY - JOUR

T1 - Development and characterization of rifampicin loaded floating microspheres

AU - Goyal, Pankaj

AU - Gill, S.

AU - Gupta, U. D.

AU - Rath, Goutam

AU - Narang, Raj K.

AU - Goyal, Amit K.

N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.

AB - Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs. © 2011 Informa Healthcare USA, Inc.

UR - http://www.tandfonline.com/doi/full/10.3109/10731199.2011.573482

UR - http://www.scopus.com/inward/record.url?scp=80052721768&partnerID=8YFLogxK

U2 - 10.3109/10731199.2011.573482

DO - 10.3109/10731199.2011.573482

M3 - Article

SN - 1073-1199

VL - 39

SP - 330

EP - 334

JO - Artificial Cells, Blood Substitutes, and Biotechnology

JF - Artificial Cells, Blood Substitutes, and Biotechnology

IS - 5

ER -

Development and characterization of rifampicin loaded floating microspheres

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this