Development of drug targeting and delivery in cervical cancer

Urvashi Aggarwal, Amit Kumar Goyal, Goutam Rath

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.
Original languageEnglish (US)
Pages (from-to)792-806
Number of pages15
JournalCurrent Cancer Drug Targets
Volume18
Issue number8
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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