TY - JOUR
T1 - Development of serratiopeptidase and metronidazole based alginate microspheres for wound healing
AU - Rath, G.
AU - Johal, E. S.
AU - Goyal, Amit K.
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2011/2/1
Y1 - 2011/2/1
N2 - The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits. © 2011 Informa Healthcare USA, Inc.
AB - The objective of this study was to establish an effective therapy system for wound management. The present work describes preparation of metronidazole/serratiopeptidase loaded alginate microspheres by emulsification method. In vitro characterizations like particle size analysis, % yield, % encapsulation, and in vitro release were carried out. Wound healing assessment was determined by physical, histological, and biochemical methods. Wound healing performance of experimental formulations was compared with marketed product in rabbits. Result obtained for alginate microspheres showed good loading efficiency with spherical in shape. Experimentation suggests wound healing is improved by using serratiopeptidase and metronidazole in full thickness wounds in rabbits. © 2011 Informa Healthcare USA, Inc.
UR - http://www.tandfonline.com/doi/full/10.3109/10731199.2010.494580
UR - http://www.scopus.com/inward/record.url?scp=78651486076&partnerID=8YFLogxK
U2 - 10.3109/10731199.2010.494580
DO - 10.3109/10731199.2010.494580
M3 - Article
SN - 1073-1199
VL - 39
SP - 44
EP - 50
JO - Artificial Cells, Blood Substitutes, and Biotechnology
JF - Artificial Cells, Blood Substitutes, and Biotechnology
IS - 1
ER -