TY - JOUR
T1 - Development of the limb neuromuscular system
AU - Sharma, Kamal
AU - Izpisua Belmonte, Juan Carlos
PY - 2001/4/1
Y1 - 2001/4/1
N2 - Appendages, such as wings of a fly or limbs of a vertebrate, are excellent models to study the principles of patterning and morphogenesis. In the adult these structures are used for a variety of behaviors, including locomotion. Although support structures of the adult vertebrate limb are generated within the limb bud, its dynamic elements are derived from the somitic mesoderm and neural tube. Recent studies show that regional patterns set up in the mesenchyme-filled limb bud guide muscle precursors and developing motor axons to their proper location within the limb. Subsequent development of the neuromuscular system is regulated by cell surface interactions between pre-specified muscle fibers and motor axons.
AB - Appendages, such as wings of a fly or limbs of a vertebrate, are excellent models to study the principles of patterning and morphogenesis. In the adult these structures are used for a variety of behaviors, including locomotion. Although support structures of the adult vertebrate limb are generated within the limb bud, its dynamic elements are derived from the somitic mesoderm and neural tube. Recent studies show that regional patterns set up in the mesenchyme-filled limb bud guide muscle precursors and developing motor axons to their proper location within the limb. Subsequent development of the neuromuscular system is regulated by cell surface interactions between pre-specified muscle fibers and motor axons.
UR - http://www.scopus.com/inward/record.url?scp=0035313836&partnerID=8YFLogxK
U2 - 10.1016/S0955-0674(00)00198-8
DO - 10.1016/S0955-0674(00)00198-8
M3 - Article
C2 - 11248554
AN - SCOPUS:0035313836
SN - 0955-0674
VL - 13
SP - 204
EP - 210
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -