Development of transmucosal patch using nanofibers

Harleen Grewal, Sanjay R. Dhakate, Amit K. Goyal, Tanmay S. Markandeywar, Basant Malik, Goutam Rath

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy. © 2012 Informa Healthcare USA, Inc.
Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume40
Issue number1-2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology

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