Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis

Rahul Sharma; Tarun Garg; Amit K. Goyal; Goutam Rath

doi:10.3109/21691401.2014.966194

Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis

Rahul Sharma, Tarun Garg, Amit K. Goyal, Goutam Rath

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The present study is designed to explore the localized delivery of fluconazole using mucoadhesive polymeric nanofibers. Drug-loaded polymeric nanofibers were fabricated by the electrospinning method using polyvinyl alcohol (PVA) as the polymeric constituent. The prepared nanofibers were found to be uniform, non-beaded and non-woven, with the diameter of the fibers ranging from 150 to 180 nm. Further drug release studies indicate a sustained release of fluconazole over a period of 6 h. The results of studies on anti-microbial activity indicated that drug-loaded polymeric nanofibers exhibit superior antimicrobial activity against Candida albicans, when compared to the plain drug.

Original language	English (US)
Pages (from-to)	524-531
Number of pages	8
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	2
DOIs	https://doi.org/10.3109/21691401.2014.966194
State	Published - Jan 1 2016
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)

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10.3109/21691401.2014.966194

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title = "Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis",

abstract = "The present study is designed to explore the localized delivery of fluconazole using mucoadhesive polymeric nanofibers. Drug-loaded polymeric nanofibers were fabricated by the electrospinning method using polyvinyl alcohol (PVA) as the polymeric constituent. The prepared nanofibers were found to be uniform, non-beaded and non-woven, with the diameter of the fibers ranging from 150 to 180 nm. Further drug release studies indicate a sustained release of fluconazole over a period of 6 h. The results of studies on anti-microbial activity indicated that drug-loaded polymeric nanofibers exhibit superior antimicrobial activity against Candida albicans, when compared to the plain drug.",

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Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis. / Sharma, Rahul; Garg, Tarun; Goyal, Amit K. et al.
In: Artificial Cells, Nanomedicine and Biotechnology, Vol. 44, No. 2, 01.01.2016, p. 524-531.

Research output: Contribution to journal › Article › peer-review

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Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis

Abstract

ASJC Scopus subject areas

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