Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development and in vitro characterization

Raffi Malik, Tarun Garg, Amit K. Goyal, Goutam Rath

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The purpose of this research is to describe the utility of nanofibers as a gastroretentive dosage form and improve the solubility of diacerein (DIA) by using the above approach. Poly L-(lactic acid) (PLLA) nanofibers loaded with DIA were prepared using the electrospinning technique. The nanofibers developed were characterized for morphology, tensile strength, floating behavior, drug entrapment, drug solubility, mucoadhesive detachment force, and drug release profile. The results demonstrated that the drug-loaded nanofibers were smooth, discrete, & non-woven. Analysis by X-ray crystallography (XRD) revealed that the drug in the nanofiber was present in the amorphous state, which largely contributes to higher drug solubility in the nanofibers developed. The buoyancy study demonstrated that the nanofibers developed exhibited zero lag time. Approximately 61.3% of drug was released in 30 h, thus facilitating the slow release of the drug from the nanofiber system. Finally, we concluded that the electrospun nanofibers developed offer a promising gastroretentive drug delivery system to deliver DIA with improved solubility.
Original languageEnglish (US)
Pages (from-to)928-936
Number of pages9
JournalArtificial Cells, Nanomedicine and Biotechnology
Issue number3
StatePublished - Apr 2 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)


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