Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

Masashi Mizokami; Johnson Y.N. Lau; Kaoru Suzuki; Tatsunori Nakano; Takashi Gojobori

doi:10.1016/S0168-8278(94)80254-8

Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

Masashi Mizokami, Johnson Y.N. Lau^*, Kaoru Suzuki, Tatsunori Nakano, Takashi Gojobori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.

Original language	English (US)
Pages (from-to)	884-886
Number of pages	3
Journal	Journal of Hepatology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/S0168-8278(94)80254-8
State	Published - 1994
Externally published	Yes

Keywords

Hepatitis C virus
Interferon-α
Molecular evolutionary analysis
Quasispecies
Selection

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0168-8278(94)80254-8

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@article{50f9f436ee184fc2ad6a135299dbb77f,

title = "Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy",

abstract = "The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.",

keywords = "Hepatitis C virus, Interferon-α, Molecular evolutionary analysis, Quasispecies, Selection",

author = "Masashi Mizokami and Lau, {Johnson Y.N.} and Kaoru Suzuki and Tatsunori Nakano and Takashi Gojobori",

note = "Funding Information: of Japan. JYNL was supported in part by the DSR-D-I 5, DSR-RDA-I-15 grants from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; the American Liver Association Hans Popper Liver Scholar Award; and the Glaxo Institute of Digestive Health Clinical Investigator Award. Funding Information: MM was supported by grants from the Japanese Ministry of Welfare and Viral Hepatitis Research Foundation",

year = "1994",

doi = "10.1016/S0168-8278(94)80254-8",

language = "English (US)",

volume = "21",

pages = "884--886",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

AU - Mizokami, Masashi

AU - Lau, Johnson Y.N.

AU - Suzuki, Kaoru

AU - Nakano, Tatsunori

AU - Gojobori, Takashi

N1 - Funding Information: of Japan. JYNL was supported in part by the DSR-D-I 5, DSR-RDA-I-15 grants from the Division of Sponsored Research of the University of Florida, Gainesville, Florida, USA; the American Liver Association Hans Popper Liver Scholar Award; and the Glaxo Institute of Digestive Health Clinical Investigator Award. Funding Information: MM was supported by grants from the Japanese Ministry of Welfare and Viral Hepatitis Research Foundation

PY - 1994

Y1 - 1994

N2 - The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.

AB - The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.

KW - Hepatitis C virus

KW - Interferon-α

KW - Molecular evolutionary analysis

KW - Quasispecies

KW - Selection

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DO - 10.1016/S0168-8278(94)80254-8

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AN - SCOPUS:0028019391

SN - 0168-8278

VL - 21

SP - 884

EP - 886

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 5

ER -

Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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