Digital holographic microscopy for study cellular dynamics

Pierre Marquet*, Benjamin Rappaz, Etienne Cuche, Yves Emery, Christian D. Depeursinge, Pierre Magistretti

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Based on an original numerical reconstruction algorithm (E. Cuche et al. Appl. Opt. 38, 6994 1999), we have developed a Digital Holographic Microscope (DHM), in a transmission mode, allowing to investigate non-invasively cellular structures and dynamics. DHM images of living cells in culture are presented. They represent the distribution of the optical path length over the cell, which contains information concerning both the cellular morphometry and the intracellular refractive index, and which has been measured with a sub-wavelength accuracy.

Original languageEnglish (US)
Article number58640C
Pages (from-to)1-4
Number of pages4
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2005
Externally publishedYes
EventNovel Optical Instrumentation for Biomedical Applications II - Munich, Germany
Duration: Jun 12 2005Jun 16 2005


  • Cell analysis
  • Coherence imaging
  • Digital holographic microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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