Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Magnus Rueping; Thomas Theissmann; Mirjam Stoeckel; Andrey P. Antonchick

doi:10.1039/c1ob05870c

Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Magnus Rueping^*, Thomas Theissmann, Mirjam Stoeckel, Andrey P. Antonchick

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

Original language	English (US)
Pages (from-to)	6844-6850
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	19
DOIs	https://doi.org/10.1039/c1ob05870c
State	Published - Oct 7 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c1ob05870c

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title = "Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines",

abstract = "A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.",

author = "Magnus Rueping and Thomas Theissmann and Mirjam Stoeckel and Antonchick, {Andrey P.}",

year = "2011",

month = oct,

day = "7",

doi = "10.1039/c1ob05870c",

language = "English (US)",

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journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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T1 - Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

AU - Rueping, Magnus

AU - Theissmann, Thomas

AU - Stoeckel, Mirjam

AU - Antonchick, Andrey P.

PY - 2011/10/7

Y1 - 2011/10/7

N2 - A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

AB - A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.

UR - http://www.scopus.com/inward/record.url?scp=80052692148&partnerID=8YFLogxK

U2 - 10.1039/c1ob05870c

DO - 10.1039/c1ob05870c

M3 - Article

C2 - 21837348

AN - SCOPUS:80052692148

SN - 1477-0520

VL - 9

SP - 6844

EP - 6850

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 19

ER -

Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Abstract

ASJC Scopus subject areas

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