Direct trifluoromethylthiolation of alcohols under mild reaction conditions: Conversion of R-OH into R-SCF3

Pavlo Nikolaienko, Roman Pluta, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF3 and BF3·Et2O to give the corresponding products in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)9867-9870
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number32
DOIs
StatePublished - Aug 4 2014

Keywords

  • alcohols
  • nucleophilic substitution
  • thioethers
  • trifluoromethyl sulfenylation

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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