Directing Group Guided Site-Selective Diversification of Indoles by Aziridine: Synthesis of β-Indolylethylamines

Ashfaq Ahmad, Himangsu Sekhar Dutta, Mohit Kumar, Raziullah, Manoj Kumar Gangwar, Dipankar Koley

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations

    Abstract

    A palladium catalyzed directing group assisted cross-coupling of aliphatic aziridines with indole, indoline, tetrahydroquinoline, and aniline has been developed to furnish the corresponding β-arylethylamine derivatives. The substrate scope was very general, and the protocol was also tolerated in the presence of various external additives. Control experiments suggested that the C-H cleavage step is the rate-determining step.
    Original languageEnglish (US)
    JournalOrganic Letters
    DOIs
    StatePublished - Apr 8 2022

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Physical and Theoretical Chemistry

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