Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells

Gustavo Tiscornia; Erica Lorenzo Vivas; Juan Carlos Izpisúa Belmonte

doi:10.1038/nm.2504

Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells

Gustavo Tiscornia, Erica Lorenzo Vivas, Juan Carlos Izpisúa Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

174 Scopus citations

Abstract

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

Original language	English (US)
Pages (from-to)	1570-1576
Number of pages	7
Journal	Nature Medicine
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/nm.2504
State	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nm.2504

Cite this

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title = "Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells",

abstract = "The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.",

author = "Gustavo Tiscornia and Vivas, {Erica Lorenzo} and Belmonte, {Juan Carlos Izpis{\'u}a}",

year = "2011",

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Y1 - 2011/12

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AB - The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

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U2 - 10.1038/nm.2504

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M3 - Review article

C2 - 22146428

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JO - Nature Medicine

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Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells

Abstract

ASJC Scopus subject areas

UN SDGs

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