Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Chenjie Xu; Keming Xu; Hongwei Gu; Rongkun Zheng; Hui Liu; Xixiang Zhang; Zhihong Guo; Bing Xu

doi:10.1021/ja0464802

Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Chenjie Xu, Keming Xu, Hongwei Gu, Rongkun Zheng, Hui Liu, Xixiang Zhang, Zhihong Guo, Bing Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

840 Scopus citations

Abstract

We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe₂O₃-DA-NTA (M = Co or SmCo_5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe₂O₃ render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

Original language	English (US)
Pages (from-to)	9938-9939
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	32
DOIs	https://doi.org/10.1021/ja0464802
State	Published - Aug 18 2004
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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abstract = "We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.",

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AU - Xu, Chenjie

AU - Xu, Keming

AU - Gu, Hongwei

AU - Zheng, Rongkun

AU - Liu, Hui

AU - Zhang, Xixiang

AU - Guo, Zhihong

AU - Xu, Bing

PY - 2004/8/18

Y1 - 2004/8/18

N2 - We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

AB - We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 32

ER -

Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Abstract

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