Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA

Walaa S. Baslyman; Othman Alahmed; Santanu Chand; Somayah Qutub; Niveen M. Khashab

doi:10.1002/anie.202302840

Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA

Walaa S. Baslyman, Othman Alahmed, Santanu Chand, Somayah Qutub, Niveen M. Khashab^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics.

Original language	English (US)
Article number	e202302840
Journal	Angewandte Chemie - International Edition
Volume	62
Issue number	25
DOIs	https://doi.org/10.1002/anie.202302840
State	Published - Jun 19 2023

Keywords

Gene Delivery
Hydrogen-Bonded Organic Frameworks
Immobilization
Self-Assembly
Zeolitic Framework

ASJC Scopus subject areas

Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.202302840

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title = "Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA",

abstract = "Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics.",

keywords = "Gene Delivery, Hydrogen-Bonded Organic Frameworks, Immobilization, Self-Assembly, Zeolitic Framework",

author = "Baslyman, {Walaa S.} and Othman Alahmed and Santanu Chand and Somayah Qutub and Khashab, {Niveen M.}",

note = "Funding Information: This work was supported by King Abdullah University of Science and Technology (KAUST). Funding Information: This work was supported by King Abdullah University of Science and Technology (KAUST). Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = jun,

day = "19",

doi = "10.1002/anie.202302840",

language = "English (US)",

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journal = "Angewandte Chemie - International Edition",

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AU - Baslyman, Walaa S.

AU - Alahmed, Othman

AU - Chand, Santanu

AU - Qutub, Somayah

AU - Khashab, Niveen M.

N1 - Funding Information: This work was supported by King Abdullah University of Science and Technology (KAUST). Funding Information: This work was supported by King Abdullah University of Science and Technology (KAUST). Publisher Copyright: © 2023 Wiley-VCH GmbH.

PY - 2023/6/19

Y1 - 2023/6/19

N2 - Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics.

AB - Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics.

KW - Gene Delivery

KW - Hydrogen-Bonded Organic Frameworks

KW - Immobilization

KW - Self-Assembly

KW - Zeolitic Framework

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DO - 10.1002/anie.202302840

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SN - 1433-7851

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Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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