Effect of a hyperlipidic diet on lipid composition, fluidity, and (na+-k+)ATPase activity of rat erythrocyte membranes

A. Bordoni, P. L. Biagi, G. Parenti Castelli, S. Hrelia, C. A. Rossi, G. Lercker, Juan Carlos Izpisua Belmonte, T. Barber, J. Cabo, G. Lenaz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Feeding rats a hyperlipidic diet in which animals were offered daily a variety of high-energy food resulted in a significant increase of serum free fatty acids and a decrease of phospholipids with respect to controls. On the contrary, there were no significant differences in erythrocyte membrane total lipid composition between the two groups. Erythrocyte membranes showed a significant decrease in saturated fatty acid content and a significant increase in (n-6) polyunsaturated fatty acid content; (n-3) polyunsaturated fatty acids significantly decreased. Membrane fluidity, investigated by fluorescence polarization of diphenylhexatriene, significantly increased in the erythrocyte membranes of the experimental group. These results seem compatible with the decreased saturated/unsaturated fatty acid ratio. A significant decrease of (Na+-K+)ATPase activity occurred in erythrocyte membranes of the experimental group rats with respect to the controls.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalMolecular Membrane Biology
Issue number1
StatePublished - Jan 1 1989


  • Erythrocyte membrane
  • Hyperlipidic diet
  • Lipid composition
  • Membrane fluidity

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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